Podporuje, jen vyřadí 1 SATA port.

1 x M.2 Socket 3*1, with M Key, type 2242/2260/2280 storage devices support (SATA mode & X4 PCIE mode)
1 x M.2 Socket 3*2, with M Key, type 2242/2260/2280 storage devices support (both SATA & x2 PCIE mode)*1

*1 When a device in SATA mode is installed on the M.2_1 socket, SATA_1 port cannot be used.
*2 When a device in SATA mode is installed on the M.2_2 socket, SATA_6 port cannot be used.

https://www.asus.com/Motherboards-Components/Motherboards/PRIME/PRIME-H270-PLUS/techspec/