Dík. Vyzkouším. Koukal jsem na limitace a např. tyhle věci mi přijdou jako dost hrozné:

Debugging managed code when the target is a 64-bit application. If you want to use Edit and Continue, you must set the target to x86. (Project Properties, Compile tab, Advanced Compiler setting.)

Debugging an application that has Attach to instead of running the application by choosing Start from the Debug menu.

Debugging an old version of your code after a new version failed to build because of build errors.