Tohle jsou tipy na funkčnost NOD32 pod Vistou:

Start the services control panel (in Administrative Tools, or services.msc)
Disable "SSDP Discovery" in the services control panel.
Install NOD32 by running as administrator, and when it asks whether or not to enable IMON, make sure to *disable* IMON in the setup.
When it asks about "Appending AV Notification to email" make sure that is disabled as well.
Reboot Vista.
NOD32 should run OK, but IMON will be off, feel free to turn it on now, and it should work.